![]() ![]() ![]() The risk of multiple cardiovascular endpoints starts to increase consistently at a hair Hg concentration of 2 μg/g.Ĭardiovascular disease Ischemic heart disease Mercury Meta-analysis Mortality Systematic review.Ĭopyright © 2020 Elsevier Inc. A J-shaped relationship between Hg exposure and different fatal/nonfatal outcomes was observed, with turning points at hair Hg concentrations of 1 μg/g for IHD and 2 μg/g for stroke and all CVD.Ĭhronic exposure to Hg was associated with an increased risk of all-cause mortality and fatal/nonfatal IHD. Occupational inorganic Hg exposure was associated with similar increases in different mortality outcomes. However, these differences were mainly due to differences in Hg exposure level. A heterogeneous relationship was found between studies reporting fatal and nonfatal outcomes and between cohort and non-cohort studies. No association was observed between Hg exposure and stroke. Dose-response meta-analyses were conducted for MeHg exposure and fatal/nonfatal ischemic heart disease (IHD), stroke, and all CVD.Ī total of 14 studies reporting results collected from more than 34,000 participants in 17 countries were included in the meta-analysis. non-cohort study, and 3) inorganic Hg vs. Note on Mercury and Cancer: No human data currently ties mercury exposure to cancer, but the data available are limited.In very high doses, some forms of mercury have caused increases in several types of tumors in rats and mice. Mercury poisoning happens as a result of too much exposure to mercury. Study estimates were extracted, and subgroup analyses were conducted to explore potential sources of heterogeneity: 1) fatal vs. 3 min read Mercury is a heavy metal that's commonly found in the natural world. Studies were selected according to a priori-defined inclusion criteria, and their qualities were assessed. We searched PubMed, Embase, and TOXLINE using previously developed strategies. To conduct a systematic review of published studies and a meta-analysis of the results to examine the associations between chronic Hg exposure and CVD outcomes. There is evidence that exposure to mercury (Hg) may be a risk factor for cardiovascular disease (CVD). ![]()
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